Best way to learn how to combine frontend and backend?

I’m pretty experienced with backend development (Java and Python primarily), as well as frontend (HTML, CSS, Javascript, etc).

I have no idea how to combine them though. I know Django and Flask are popular, but are they the easiest way to learn and get the job done? Also, feel it’s important to note I rather not do Node.js just yet.

They come together with GET requests or API calls to the server. If you want to go python then Django is for sure the beaten path and is probably the easiest.